Hemostemix Sells Its 23rd ACP-01 Therapy Convertible Debenture

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Calgary, Alberta--(Newsfile Corp. - March 5, 2025) - Hemostemix Inc. (TSXV: HEM) (OTCQB: HMTXF) (FSE: 2VF0) ("Hemostemix" or "HEM"), an autologous angiogenic stem cell therapy company that has safely treated 498 patients for various forms of cardiovascular disease, including peripheral arterial disease, chronic limb threatening ischemia, non ischemic dilated cardiomyopathy, ischemic cardiomyopathy, angina, congestive heart failure and vascular dementia, announces the sale of 15 ACP-01 Therapy Convertible Debentures for proceeds of USD $517,230, subject to the approval of the TSXV Exchange.

"Year-to-date, this sums to forward sales of CAD $1,149,983, which is gratifying, as it generates non-dilutive working capital for our company and its shareholders," stated Thomas Smeenk, CEO. "Importantly, forward sales enable the scheduling of both production and physician time in a very orderly manner. More over, forward sales generate a ramp-up of production from 20 to 40 treatments per month, and from 40 to 80 treatments per month, from revenue. Given 20 treatments per month generate annual revenue of USD $8,880,000 (CAD $12,876,000); given one physician completing four (4) blood draws per day generates 80 treatments per month (4 x USD $8,880,000); shareholders can quickly understand how we scale operations to our run rate as we announce additional forward sales and agreements with clinics and clinicians, globally," Smeenk stated.

An unsecured obligation of Hemostemix Inc., each ACP-01 therapy convertible debenture ("TCD") is convertible into an ACP-01 therapy on a first purchased basis. Transferable, saleable subject to a Hemostemix ROFR, will-able, and convertible into equity at the option of the Purchaser, each TCD collects interest at 6% per annum payable annually in shares of Hemostemix at the average closing price per share for the ten days preceding December 31st of each year. TCDs may be listed to trade on a stock exchange at a date in the future.

ABOUT HEMOSTEMIX

Hemostemix is an autologous stem cell therapy company, founded in 2003. A winner of the World Economic Forum Technology Pioneer Award, the Company has developed, patented, is scaling and selling autologous (patient's own) blood-based stem cell therapies that include angiogenic cell precursors (ACP-01), and later neural cell precursors (NCP-01), and cardiomyocyte cell precursors (CCP-01). Hemostemix has treated 498 patients, completed seven clinical studies of 318 subjects and published its results in nine peer reviewed publications. ACP-01 is safe, clinically relevant and statistically significant treatment for peripheral arterial disease, chronic limb threatening ischemia, non ischemic dilated cardiomyopathy, ischemic cardiomyopathy, congestive heart failure, and angina. Hemostemix completed its Phase II clinical trial for chronic limb threatening ischemia. For more information, please visit www.hemostemix.com.