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LONDON and PHILADELPHIA, March 26, 2025 (GLOBE NEWSWIRE) -- Avacta Therapeutics (AIM: AVCT), a life sciences company developing next generation peptide drug conjugates (PDC) targeting powerful anti-tumor payloads directly to the tumor, today announced that the Company will have three presentations at the American Association for Cancer Research (AACR) Annual Meeting from April 25-30, 2025 in Chicago, IL.
The poster presentations will feature data from the Company’s proprietary pre|CISION® platform and pipeline of next generation peptide drug conjugates (PDCs), including AVA6000, a PDC consisting of doxorubicin conjugated with a peptide moiety that is specifically cleaved by FAP in the tumor microenvironment via a pharmacokinetics and clinical presentation, and preclinical pharmacology highlights for AVA6103, a PDC comprised of the pre|CISION® peptide linked to exatecan. The third presentation will describe detailed analysis of the target fibroblast activation protein-alpha (FAPα), the protease that forms the basis of the pre|CISION® platform.
Details for Avacta’s poster presentations are below and can be found on the AACR website:
Abstract Number and Title: #3139: The novel PDC AVA6103 is a FAP-enabled pre|CISION® medicine which targets exatecan, a topoisomerase I inhibitor, to the tumor microenvironment following FAP cleavage
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Session Category: Experimental and Molecular Therapeutics
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Session Title: Therapeutic Approach to Attack the Tumor Microenvironment
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Session Date and Time: Monday, April 28, 2025, 2:00 - 5:00 p.m. CT
Abstract Number and Title: #2699: Investigating fibroblast activation protein alpha (FAPα) as a therapeutic target for delivery of pre|CISION® cancer medicines: Expression, spatial localization and functional insights
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Session Category: Tumor Biology
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Session Title: Targeting the Tumor Microenvironment: A Brave New World
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Session Date and Time: Monday, April 28, 2025, 2:00 - 5:00 p.m. CT
Abstract Number and Title: #CT15: Comparative pharmacokinetics and tumor activation of fibroblast activation protein (FAP)-enabled pre|CISION® peptide drug conjugates
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Session Title: First-in-Human Phase I Clinical Trials 2
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Session Date and Time: Tuesday, April 29, 2025, 9:00 a.m. - 12:00 p.m. CT
For further information from Avacta, please contact:
| Avacta Group plc | |
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| Peel Hunt (Nomad and Broker) | |
| Panmure Liberum (Joint Broker) | |
| ICR Healthcare | |
| Investor Contact | |
| Media Contact |
About Avacta - www.avacta.com