Yahoo Finance

Joseph Hazelton

Joe, thank you, Mark. 2024 was a transformer of the year for Dietic International as we advanced our mission to improve global access to affordable, high-quality proteins through our C1 and Davis microbial protein production platforms.
While Dianic remains committed to human and animal health platform and product opportunities for mid to long-term growth, today, I want to emphasize our progress and near-term revenue potential in the non-pharmaceutical and re-agent product markets, which continue to show robust momentum and commercial readiness across our three areas of focus in alternative proteins life science, food nutrition, and bio-industrials.
We're making strong strides toward commercializing several cell culture media components, each addressing growing industry demand for animal-free, cost-effective, and high-performing alternatives in the life science segment of alternative proteins. Recombinant human serum albumin, RHSA, being developed through our partnership with Proliant Health and Biologics is on track for a commercial launch in 2025.
RHSA is a foundational product for diagnostics, bioproduction, and vaccine formulation.
Our recombinant transferring product is also progressing well with active partner engagement and sample distribution underway. In initial self-proliferation studies, dyadics recombinant transfer in protein demonstrated comparable performance to a recombinant reference standard, highlighting its potential as a high-quality, cost-effective, non-animal alternative for research and commercial bio-processing applications, and we are currently exploring opportunities for scale up and licensing.
Furthermore, Diattic is advancing the development of recombinant fibrobbreast growth factor, FGF products for cell culture media and biopharmaceutical applications. As a critical driver of cell growth and proliferation, the combinant FGF plays an essential role in biomanufacturing, regenerative medicine, and cell-based therapies, particularly in serum-free and chemically defined cell culture media.
Initially, self-proliferation, initial self-proliferation studies have demonstrated that dynamics recombinant FGF products exhibit comparable performance to reference standard recombinant FGF. In addition to further characterization and validation efforts, sample initiatives are expected to begin in Q2 2025. These cell culture media components position dyadic to capitalize on growing bioproduction needs with high quality non-animal cost advantage solutions.
In the alternative protein, food and nutrition space, dyadic is unlocking new opportunities across non-animal dairy, nutritional science, and research applications. We are actively developing high-value recombinant way and other proteins, including alpha lacta abdomen, caseines, and human lactofen, all of which are in high demand for use in infant nutrition, functional foods, wellness products, and pharmaceutical applications.
Sampling and optimization efforts are ongoing with increased interest from potential collaborators across the R&D and non-animal dairy sectors. These proteins offer a sustainable animal-free alternative to traditional dairy-based ingredients, addressing a growing consumer and industry shift towards ethically sourced and health promoting proteins.
In parallel, our dairy enzyme portfolio is progressing rapidly through our partnership with an EU-based commercialization partner. In 2024, we achieved a productivity milestone of $425,000 for one of our recombinant dairy enzymes with a commercial launch anticipated in late 2025. Additional enzymes are in development under our licensing agreement signed in 2023, expanding our reach into dairy processing and functional ingredient applications. Together, these programs provide dyadics with a strong foothold in the expanding animal-free dairy and specialty nutrition markets where the demand for scalable, functional, and animal-free protein solutions continues to accelerate.
Dyanic is also making significant progress in the life sciences segment of our alternative proteins business with the development of a suite of DNA and RNA related reagent enzymes, which are a natural and strategic fit for our proprietary platforms.
One of the leading candidates in this vertical is our RNA-free DNase-1 enzyme, which is now in the final stages of process validation.
We're actively partnering with the European Contract Development and Manufacturing Organization, or CDMO to initiate research grade production. This enzyme serves a broad range of applications, including molecular diagnostics, gene therapy, and biologics manufacturing, where high purity and consistency are essential.
In addition to DNase-1, sciatic is expanding its enzyme portfolio with the development of 4 additional reagents, including RNAse inhibitors and T7 RNA polymerase. These are foundational tools in DNA and RNA manipulation, in vitro transcription, and next generation sequencing workflows, which are key technologies that support genomic research, therapeutic development, and synthetic biology.
Early development and optimization efforts are progressing with initial data and validation results expected by the end of 2025. This free agent enzyme market offers dyadic a scalable recurring revenue opportunity with relatively low regulatory hurdles and a shorter path to market compared to traditional biopharmaceutical products, enabling faster commercialization and greater near-term impact across our life sciences sector.
Dianic is also advancing its presence in the bio-industrial sector of our alternative protein segment, where our dapibus protein production platform is being leveraged to support sustainable large-scale enzyme solutions across multiple industries.
In 2023, we entered into a development and commercialization agreement with Farm Box Bio, a synthetic biology research and manufacturing company.
This collaboration led to a significant milestone in May of 2024 with the launch of Erezyme, an enzyme cocktail produced using dyadic staff of this platform. Erezyme is specifically designed to enhance the efficiency and cost-effectiveness of converting pre-treated agricultural residues into fermentable cellulosic sugars, which is a key part of the critical process in the production of renewable chemicals, biofuels, and other bio-based products.
Beyond this partnership, Dianic has continued to develop a broader portfolio of enzymes with potential applications across across a wide range of bio-industrial markets, including nutrition, biogas production, biofuels, and bio refining. These enzymes are currently being sampled and evaluated by interested commercial partners as we work to identify optimal fits for industry-specific use cases. This segment represents a promising area of growth where we believe our platforms can contribute to reducing reliance on fossil fuels and improving the economics of sustainable industrial processing.
While the alternative protein segment drives near-term focus and revenue, our longer term value in human and animal health is supported by our ability to partner with leading global institutions.
As part of our ongoing strategy to expand the reach and impact of that platforms, we continue to strengthen our position through strategic grants and non-diluted funding partnerships that support long-term innovation.
Last week, we announced a significant milestone with the receipt of a $4.5 million dollar grant from the Coalition for Epidemic Preparedness Innovations, or SEPI awarded to Fonacion Biotechnopola Da Siena, or FPS to accelerate the development and manufacturing of recombinant protein vaccines using dyadic C1 platform. With the project already underway, this funding will support key steps including antigen design, cell line development, process optimization, product characterization, and scale up CGMP manufacturing.
As a subcontractor on this initiative, the attic is expected to receive $2.4 million of the total grant amount.
In November of 2024, Dyne was awarded a $3 million grant from the Gates Foundation to supportsine development for monoclonal antibodies targeting respiratorial syo virus or RSV and malaria.
These programs powered by our C1 protein production platform, are focused on delivering affordable, scalable solutions for treating infectious diseases in underserved populations, further aligning our work with global health priorities.
In collaboration with FBS and other partners, Dade has also submitted multiple new grant applications aimed at expanding the development and adoption of the C1 platform across additional vaccine and antibody programs. As a very recent example, on March 23rd, SEPI announced the award of a $2.6 million dollar grant to Uyo. This funding will support the development of a MERS vaccine and research to assess the capability of the C1 platform to speed vaccine production and lower manufacturing costs, improving access to vaccine doses in the future.
These ongoing efforts not only bring in meaningful financial resources to advance research and development, but also enhance our global visibility and validate the competitive advantages of our platform in addressing urgent health challenges worldwide.
Dianic continues to advance its pipeline of innovations in both animal and human health, demonstrating versatility and rapid development capabilities of seawater.
In collaboration with Vovacs were developing C1 produced self-assemblinger to nanoparticle antigen targeting H5 avian influenza, or bird flu for potential use in diagnostics and vaccines across poultry, cattle, humans, and companion animals.
With the ongoing bird flu outbreak posing significant risk to both agriculture and public health, we are actively conducting pre-commercial research and validation to support potential strategic partnerships and licensing opportunities.
Additionally, our Mpox vaccine, or monkeypox vaccine candidate also developed a partnership with Verva is an early stage pre-clinical development.
This project not only expands our infectious disease portfolio, but also provides further validation of the C1 platform's ability to rapidly produce cost-effective non-MRNA vaccine candidates.
In diagnostics and vaccines research, our C1 produced adjuvanted ferritin nanoparticle H52.3.4.4b astrocon vaccine has shown cross protection against multiple H5 virus strains in early studies. In poultry, early trials demonstrate the generation of neutralizing antibodies, supporting the potential for commercial viability in both vaccine and diagnostic applications. In cattle, preliminary diagnostic and vaccine data have shown similar cross-protective potential, opening the door to a broader addressable market in the livestock health segment.
We're also, we've also expanded our collaboration with Firo Animal Health, or AI Biological Laboratories to develop vaccines for diseases affecting livestock animals. This partnership strengthens our strategic position on animal health and further supports the application of C1 as a cost-effective and scalable solution.
Beyond these programs, Diantic has also successfully expressed a high yield, high purity RSVF trimer antigen, along with several other antigies of monoclonal antibodies. These developments further validate the flexibility and efficiency of the C1 platform in addressing a wide range of human and animal health challenges while continuing to support our longer term biopharmaceutical pipeline.
With that, I will turn the call over to our CFO Ping Rosson to cover our financials, Ping.

Ping Rawson

Thank you, Joe.
Thank you everyone for joining our call today. I will now go over our key financial results for the year ended December 31, 2024 in more detail. You can find additional information in our earnings press release and Form 10k, which we filed earlier today.
As of December 31st, 2024, we have cash equivalent and investment grade securities of approximately $9.3 million compared to $7.3 million as of December 31st, 2023.
Revenue for the year ended December 31st, 2024 increased to approximately $3,495,000 compared to $2,899,000 for the year before.
The increase is driven by the licensed revenue of $1 million from per line and approximately $890,000 from enzymes, including Success fees in 2024.
Cost of research and development revenue for the year ended December 31st, 2024 decreased to approximately $1,195,000 compared to $1,976,000 for the year before.
The decrease in costs of revenue was due to higher individual contract amounts on certain research funding and related work performed during 2023.
R&D expenses for the year ended December 31, 2024 decreased to approximately $244,000 compared to $3,297,000 for the year before.
The decrease was due to the completion of the company's phase one clinical trial of DYF 100 COVID-19 vaccine candidates.
GNA expenses for the year ended December 31, 2024 increased to approximately $6,135,000 compared to $5,817,000 for the year before. The increase reflected increases in business developments and investor relation expenses of approximately $294,000 share-based compensation expenses of $109,000. Professional service expenses of $82,000 and other increases, partially offset by decreases in measurement incentive expenses of $124,000 legal expenses and insurance expenses.
Law firm operations for the year ended December 31st, 2024 was approximately $5,901,000 compared to $8,230,000 for the year before. That loss for the year ended December 31, 2024 was approximately $5,809,000 or $0.20 per share compared to a net loss of $6,795,000 or $0.24 per share for the year before.
As previously disclosed, the company was awarded a 3 million grants from the Gates Foundation in November 2024. Additionally, in March 2025, our partners received the two awards from SAPI to support C1 antigen development and accelerate the advancements of the C1 platform from which we expected to receive additional fundings.
These initiatives are expected to create additional revenue growth opportunity in 2025.
Now, I will ask the operator to begin our Q&A session, after which, Mark Emelar will provide closing remarks. Operator.

Question and Answer Session

Operator

Thank you. (Operator Instructions)
John Van dermosten, Zach Small Cap Capital Research.

John Vandermosten

Great thank you and how you doing Mark Ping and Joe?
I thought I'd start out with a question on the Gates Foundation and SEPI grants. It seems like there's a lot of interest in them and you and I'm, I heard you mention that there are some other other grant applications that you had made maybe you can reconcile, I guess you know how the Gates Foundation fits in and if some of those grants are in that area and also the, their interest in C1 because it seems like. They they've done a number of things that that recognize its value.

Mark Emalfarb

Yeah, thanks, John. To address your first question, yes, we have a number of additional grants we've applied and or collaborators of applying for the ones embedded in those programs, and that's both for Gates and SEPI as well as other nonprofit organizations, government grants in different countries.
So I, of course, you can tell by the Gates giving us a $3 million dollar grant. They have a significant interest. We've been having, calls with them already. I think they're excited about how fast they see from the work we're doing compared to the cells that traditionally used to seeing with the monoclonal antibodies. In fact, they mentioned how surprised they were, how fast we were already getting transformance.
And SEPI we're just getting started, but I think the key here that I think you pointed out is these are two of the largest nonprofit funding organizations on the planet related to vaccines and antibodies and global health.
So I think that that the money that we're getting directly and through these. Foundation biotechnical the Sienna, the the grant announced yesterday by SEI with U Bio. The these are driving forward the innovation and the advancement of our platform not only to make it. Quicker, faster, better, and cheaper because quite frankly, it's already produces things at remarkable levels fast and quick, but it's bringing adoption and use to potential products that are going to be put into human beings at some point, down the road that we hope to turn into life saving medicines that we can make. Profit on from our shareholders would bring global health to the humanity. And then on the animal health side, fibro, as Joe mentioned, is advancing towards commercialization on one or two of the animal health vaccines. And as with the USAA just announced recently, a billion dollars in funding for potential human health or animal health. And 100 million of that is partly going to be assigned potentially for vaccines, and we actually got notice yesterday from them of a potential opportunity to apply for that grant, which we intend on evaluating and potentially doing on our own and are in collaboration with academics and industry and nonprofit organizations. So hopefully that gives you a flavor for the fact that quite frankly, we're seeing more interest in our platforms, our technology, and the products we're producing than we've ever seen.

John Vandermosten

Okay, and you know we're all excited about the album in sales, and Joe, I think last time we spoke a couple months ago you were walking through some of the steps that you needed to complete before getting that first product revenue dollar through the door. Can we revisit kind of how you've come along since then and and it seems like, maybe in the next weeks or month or so, yeah, that milestone may happen of getting that dollar through the door, can you update us?

Mark Emalfarb

Yeah, absolutely, John, and first of all, thanks again for the questions. Always appreciate your perspective on these things and when you look at the Albumen market, obviously we're excited to enter into commercialization. The, I think that the key for us is continuing to rapidly accelerate scale up and we're doing that in conjunction with Proliant health and biologics. We have made progress and obviously we have to do it right. We have to make sure the product's validated the QC testing is done and it's produced, according to the right specifications in order to have a successful launch. In addition, starting to sample that's going to be the first key which we do hope and it will be happening very soon. But again, we remain committed to pushing and hopefully commercializing in the early 2025, so we're still pushing it, it's still about scale up and making sure the product is qualified. And that just takes time. There's really no shortcuts you can take. It's kind of like, I don't want to say developing a drug, but in some instances you do have to make sure you meet the right product specifications, especially if you want your customers to be switching to a recombinant product versus let's say an animal derived. So you want to make sure everything is, basically all set and all. Just point to go before you put a product on the market and then realize something is wrong so we're just making, extra sure and doing all the qual qualifications in QC to make sure these products are high quality, high purity, and that they'll meet our customers' needs and, again, hopefully we still, continue to push and have that commercialized as quickly as possible.

John Vandermosten

Okay great thanks too I'll hop back in line.

Operator

Bernon, Bernardino with HC Wainwright.

Hi everyone, thanks for taking my question and congratulations on the great quarter and the, getting this grant.
I was just wondering if you can help us a little bit with determining the the cost of research and development revenue just wondering if you could talk a little bit about the components that help us how to figure that out.

Mark Emalfarb

Well, I think the important part is 80% of the research and development expenses are covered by somebody else with some profit margins built in for us.
So the SEI grant for the 4.5 million of which we're going to get 2.4 directly, but the 4.5 million is all going towards developing C1, as Joe pointed out, towards phase one launching capabilities and increasing the speed to keep up with mRNA proteins and vaccines. And we believe actually that, we can do that and we've demonstrated that we can create stable cell lines already within 21 days. They're very fast and they're very productive and they're mass producible at very low cost without the need for cold extreme cold chain storage. But I think the point here is all that money is advancing this platform and innovation and driving it to the point where adoption and use in big pharma, governmental agencies, academia, it all starts by putting the gene into a cell line and like Uve bio in in the SEPI grant that was announced yesterday, where they're getting $2.6 million from SEPI to advance their marriage program.
We're going to produce the antigen that goes in there, that's going to be ultimately the vaccine, the active component of the vaccine.
So the more of these opportunities we get, the more demonstration of safety, efficacy, speed, yield, cost. The momentum is building and it's accelerating. And as we mentioned in the past, Reno Rapioli is one of the godfathers of the vaccine space. He's the head of the Foundation of biotechnologies Sienna. It took us longer than we expected to get embedded there, but he's been out promoting our technology for over a year and a half to a variety of different government organizations, pharmaceutical companies, academia, etc.
And we expect more things to come from that collaboration in the not too distant future.

Great. And follow up on the SEPI grant. The grant is to FPS, right? The, press release said that, yeah, the C1 produced protein engines can be compared to traditional, mammalian approaches. Just wondering, what is FPS's experience with that and when can we see, results from their work?

Mark Emalfarb

Well, FBS experience is probably 30 years with Marina Rapioli as a former GSK, Chief Scientific Officer at Novartis before that, at Chiron before that. As I mentioned, he's like one of the godfathers of vaccinology. He's probably taking 10 or 12 drugs through the clinic and commercialization over time.
So the good news is that we've seen already in in another funded program where we've actually worked with UC Davis and we're working on that publication that the C1 produced full spike protein actually performed virtually identical to the hex cell protein.
So we we're expecting very good results from that program very soon.

So will the comparison be, in vitro or?
Some kind of year year old number.

Mark Emalfarb

So it'll be in animal models, which is what we've already done.
So you'll see when the publication comes out that we can virtually make same thing, same quality, same efficacy, just faster, quicker and cheaper without the need to do viral clearance. So in the downstream we can speed it up with less cost. On the upstream we can blow it away in terms of speeding costs, and we've already seen, at least in the mice trials that have been compared head to head. At least with the microneedle approach, then we were equal to the hex cell, which is actually a human cell, which is actually better than the show cell.
Great.

Thanks for taking my question and congrats again. I'll get back in the queue.

Operator

John Vander Moten with Zach Small Capital Research

John Vandermosten

Great, thank you. So you had mentioned that by year end that you may begin commercialization of the dairy enzyme. Can you also walk me through the steps there kind of like you did with the with with the album and what what needs to get done before again that first dollar can flow through the door?

Mark Emalfarb

Sure, John, it's Joe, and again, thanks. This is similar, I guess a little bit to research grade in terms of it does require some level of regulatory oversight in cases of food proteins or enzymes, depending on the market you're launching into, for Europe, it's, part of the EMA, that deals with food type of food proteins in the US, it's grass. So essentially the product has been filed for self affirmed. Brass application, that should hopefully be I think it is submitted and and once that is clear, then they just do the final testing and production and then they'll be able to put it on the market. So it's similar in terms of the steps obviously you need to scale up, prove the quality, in some cases like in the EU, you do need to do animal testing. Of food proteins or food enzymes, versus the US where it's a little less stringent in some cases, but overall, it's a slightly different, less intrusive regulatory pathway, so they're a little quicker, but you still do have to make sure that you follow the process for development and scale up and then ensure the quality of the product and and that it is food grade moving out the door. So right now as it's scaling up in a food grade production facility, they're parallel tracking the grass application so that that's essentially the main process.

John Vandermosten

Okay, and 11 other question for you on productivity. Do you have the numbers in terms of grants per liter per day for the various applications that you have, the human slash animal albumin, the transfer and the growth factors kind of what's the relative, efficiency of those in terms of grant per liter per day or or whatever, time period that you're using?

Ping Rawson

Yeah, Joe, I think that some of that proprietary information, so we just leave it to be obviously high enough that we're getting commercial traction, and I'm glad you brought up transferring and Growth Factors DNAse one, alpha lacta albumin, because Joe, maybe you can expand on all the excitement and interest and progress we've made on all those products maybe one by one.

Mark Emalfarb

Yeah, and I think the key, John, as you look at in terms of productivity is that we are able to basically, make better margins than traditional or common products on the market today due to our productivity and Marks right we can't get into the. The specifics, but suffice to say that the interest that we're receiving in our non-pharmaceutical applications, as Mark mentioned, whether it's transferring in cell culture media, is due to the high productivity. These enzymes and cell culture these proteins and cell culture media like albumin, like transfer, they are thousands of dollars per gram or even in some cases per per microgram. So it's very important that we're able to, use the productivity. Of the system to help not only bring the cost down, enables commercialization like cell culture media can be used in pharmaceutical development and manufactured, at CGMP levels, but it's way too expensive for markets like cultured meat. And the nice thing about the cell culture media market that we're entering into is it does serve two different areas of the business, whether it be production of lab grown meat or growing. Show cells to you know manufacture, biologics so that essentially we're able to use these portfolios and cell culture media in two different directions, basically expanding and in some cases, doubling and tripling our potential profit margins in these markets, and we're making great progress in the testing as Marin mentioned, with the transferring the growth factors, being able to demonstrate that we can grow animal cells just like the product. They're using today except at much higher yields and potentially much lower prices is very interesting and that's what's driving really the unprecedented interest that we're getting in the platform right now, not just in the alternative protein space, but also in the pharmaceutical space. So I think, we got, we can't get into the specifics, but if you look across these products, they're all moving forward as quickly as possible, and that is going to be our focus as commercial Virtualization of products either ourselves or through through partners, as Mark mentioned DNAS one, we're getting ready to, partner with or we are partnering with the CDMO to scale up a research grade production of DNAse one that we can begin to commercialize ourselves or you know sell in bulk to to others to sell. So I think we're positioned correctly in the right high value segments. It's just obviously making sure that we continue to develop these products as quickly and efficiently as possible.

John Vandermosten

Okay great thank you.
Dick Williams with Williams Resource Group.

Dick Williams

Yeah, hi, gents. I wanted to touch on a couple of things, having been a shareholder for a great number of years and gone through the projects that didn't really materialize.
It seems that Zapy, it was one for 5 years. We were picked as the best technology for the future. It seemed it was unanimous and of course that the whole group, including AstraZeneca has really not done anything.
But it appears that the sipppi is is something that will happen.
The one, other factor with the Sippi release was they also had put out a release that I got buried in their material with UFA where they mentioned that they had given them the $2.6 million but also in the vaccine development, whatever it is for, that they would be using the C1 manufacturing.
System for whatever it was, which obviously gave us some good accolades that didn't get much attention but it was buried, but that was significant.
And now we finally have an opportunity with an organization that appears to be making product that will be sold and we'll start to get revenue because I think Joe, in terms of your area, it's so significant. If we were to dissect it down to TRY to See where the revenue stream opportunity comes from from these various products in the margins. I mean, we'd probably be on the phone for 4 hours, but can you give us an idea as to the market size, opportunity, and some of the segments in your area that you mentioned as well as probably and.
I've checked out pro and it's a very large corporation. This is a mom and pop, guys. They have a full worldwide sales force, several manufacturing facilities, and they're going to launch a product that we will get revenue from in a matter of months, I presume I, we don't have a date, but I believe it's somewhat in a matter of months. And this is serious revenue that could flow to us, and probably the most immediate revenue for us of size.
So can you give some more color on where that is? I know you talked to John about the research aspects and the technical aspects. I like to hear about the money aspects, profit motives, and revenue streams that can come in from all of these projects. And this will be the refreshing part of the new dyadic. For 5 years, all we've heard was research projects with no revenue. We finally have arrived at the point where now we can produce revenue for all of the stakeholders as well as for the people on Wall Street to give the recognition we so truly deserve.
So can you kind of dissect it and and then the other thing, excuse me, is another factor that has kind of gone, I think fallen by the board because we're doing so many things and we see the market opportunities for them, but I was around 5-6 years ago when this company did upwards of close to $100 million over I forget what period of time in the bio-industrial sector.
Real revenue produced by Mark before Joe joined with this new area and that area I understand is blossoming again and one of the opportunities for us to go back into And offer the products we now have for that industry. So can you give some color of where we are and what type of an effort mark you're going to put forth to go back to your old people and get some serious revenue from them?

Mark Emalfarb

Yeah, well, let me answer the first question for.
The.
Last.
I know it's a mouthful, but you.
I look, we're going to run out of time here, so I love you. We appreciate your thoughts. You're a great supporter. We love all our shareholders and partners and employees, but we didn't just twiddle our thumbs in the last 5 years. We developed platforms first.
From pharmaceuticals to revolutionize and transform speed, cost and yield and release, and you have to have a platform before you can make a product. You can't make a product in an inefficient platform or you're going to fall short or it's going to be people are going to die or suffer and which is what's happening in the world.
And we took the time and effort to do it right, and we got a ton of funding from pharmaceutical companies. We spent some of our own money on it.
We got funding from government agencies, you had the Israeli government, you had the EU ZAI program, you had all kinds of things coming in that advanced it to make and wake up the Gates Foundation said didn't you just wake up yesterday. We've been talking to these people for years.
It got to the point that they recognized that we actually have the keys to the kingdom to really improve speed yield, cost, and release of not just pandemic, we're talking about traditional oncology drugs, arthritis, dementia.
Alzheimer's, you name it, we can probably make it in a in a more efficient way at a lower costs faster. And once we get these things into the clinic and through the clinic, the doors are going to open up. So if you don't have a platform, you can't do any of this. So, we haven't just been twilling ourselves for 5 years, and these guys didn't just show up. They showed up because we actually did what we said we were going to do and we did it for a fraction of the cost that most other people would have done.
On the industrial side or the alternative protein and Joe's going to answer all those questions. We started with Dappabus to do the same thing at an accelerated pace, taking the learnings and education that we have and our CDOs and research partners have, and we've brought this out very rapidly, very quickly to do, as you point out, to go after an industry that's even more valuable than the one we did before when we generated. 30+ million in non, let's say diluted funding from Shell, Amigo, BIOS, BASF, and then there's 75 million from DuPont. But alternative proteins for alpha lactaalbumin for transferring for FTF for DNAse one, those margins are much higher than what we had in the industrial section, albeit we are going after some of those industrial products. And Joe will talk about this, so now I'll let you go, but without these platforms we wouldn't be making anything and our customers would be making anything that would be commercialized.
So let's just leave it there and Joe, maybe you can jump in.

Joseph Hazelton

Yeah, and Vicky, I think you hit the nail on the head, the markets that we're entering into are by design and they're high value markets where our technology has a significant advantage in terms of its productivity. If you look at the human albummen market, that's roughly a $5.6 billion dollar market, and I believe it's growing at double digits per year, and that's driven by a lot of the increase in the amount of vaccines being produced, not just in human health, but also in animal health. And as we look to some of the other markets like DNase-1 and other RNA DNA and RNA enzymes, that, that's a, the DNA or the endonuccleus market, the DNase and ligase market is around $900 million. And again it's growing at at almost double digits, I believe a year as well. You look at things like non-animal dairy proteins, that's a $26 billion dollar market. And that's where like alpha lacta, albumin, lactofen, those things can play. Each of these products also has a distinct, not all of them, but some of them have a distinct market like alpha lacta albumin. It doesn't just play in the non-animal dairy space, it also potentially can play in pharmaceuticals, and it plays as a research rate agent for nutritional and biochemical studies. So each one of these products has, different markets, but I think the key that I want to emphasize though even though we're we're in all of these markets and we're developing products for high value segments, what we do remains the same. We develop cell lines, but that's what we do. We take a DNA sequence and we put it into our cell lines. So we're, while we're targeting multiple, areas.
We're targeting the right partners, as you mentioned with the Proliant Health and biologics. They're a major player in the men space, you look at, even UX Bio, you look at SEPI and Gates, we, we're targeting the right partnerships and the right, potential partners for these products because we can't do it as as dyadic. And I think that's the key. What we're doing remains the same, we're staying focused on that. And that is creating products in these non-pharmaceutical or reagent segments that we can quickly commercialize due to the fact that we have high productivity and obviously potentially lower costs for the sectors what's driving the interest. So you look across, there's there's not a lack of available market to go after. It's getting the product to the market and and. To find the right partner to help us commercialize and that's that's really what we're trying to do right now. But I think, we're seeing unparalleled interest in all of our segments right now and it's due to the fact that we are starting to move closer to commercialization and I think as soon as we get the first product on the market, that's going to be another driver for us or another inflection point that we can use to continue to expand the adoption. So I think you know hopefully that gives you a flavor for the the size of the markets that we're going into and the the capability that that are are potentially that these products can have.

Operator

Thank you. And our next question comes from Tony Bowers with Introact.
Please proceed with your question.

I applaud, Mark for his patience and persistence on the human side, but, thankfully we've got, what Joe's been working on, particularly in this environment. Given the sort of international turbulence, the, turbulence in Washington, is there anything that is kind of obstructive other than the uncertainty of grants, to your business plan? And then a separate question is, where do we stand with all of the great work that was done in South Africa and the provenance that you've developed there, and how long will it be before we see all sorts of biologics with dyadic inside the way we've seen Intel inside computers?

Mark Emalfarb

Tony, good questions. First and foremost, we are completely focused on the non-pharmaceutical side of the business to drive revenues.
We're developing multiple products there.
But at the same point we're not going to turn down $7.5 million for the financing non-diluted funding that we have some profit in to advance the platform and the learnings that we get from the pharmaceutical side of the development we can apply also in our applying on the other side, okay, but our focus is currently driven by.
Albumin transfern DNase 1 alva lacta albumin, we're developing some cellulosic enzymes for biogas, bio refining, cellothic sugars. So Joe can jump into all that, but I want you to know that yes, we realized that the environment has changed, but long before the environment changed, we started targeting these other areas that bring in revenue and profits sooner.
So Joe, you want to go into that? .

Joseph Hazelton

I mean, I think we probably hit the markets pretty well. I think the key Tony though that you've mentioned, what we're doing with, Rubic in South Africa, where that stands right now they've shifted their focus to animal health and animal health vaccines, and right now they're developing, I believe up to 5, animal health vaccines because they're a little obviously easier. Commercialized in human vaccines at this point. The phase one study that we completed with rubic for DAA 100 was a milestone event for dyadic, and I think it's it's what's helping drive this increased interest from people like Gates and SEPI and the fact that we have been in humans with a protein produced in the system. Unfortunately, we were a little bit late to the party in the COVID space, and I think you will continue to evaluate that with rubic, but right now their focus has shifted towards animal health, and I know that they're looking to hopefully, have something, have some clinical studies, at the, I think the tail end of this year. So I think there's definitely an opportunity there. It's just we're probably going to do it in animal health before human health in that market.
It's expected.

That Yeah. Well the animal health products have to be funded by a government program?

Mark Emalfarb

I don't know if they necessarily need to be funded by a government program, but they could be, I think they're also looking at other sources of funding and revenue as well, so I don't know, Mark, if you have any greater insight there.

Joseph Hazelton

Yeah, actually I'm heading there, next month, so I'm going to go down to, Johannesburg, and I'm going to have a meeting with them for 2 days. I do have a little more insight than Joe does because I'm I'm not going there, and they already have, I think they're working on a challenge study already. It's already funded for for an animal health vaccine. And they also have from what I understand, they have, either have received a grant or will be receiving a grant for $1.8 million for equipment and things like that working towards getting ready to TRY to build a facility down there. And I do believe that they're also, as you pointed, raising capital, not from government grants but from equity to bring in several million dollars to accelerate those efforts. But I'll have a lot more clarity when I get down there, but I've been in touch with them recently on a constant basis and that they're moving forward, so they're doing very well.
They're not going as fast as we'd like, but they also don't have the. Wherewithal to do with the funding that we can get in the United States, but the whole issue I want to bring up, I think it's important because it's the elephant in the room, what Trump and Eli Musk are doing in Doge and and cutting out all these different programs. Guess what? We don't have any of those US government programs, so we're not getting gutted, but the thing is, there's a shift. And the shift is going to cost efficiency, lower cost, save government money. In some ways, what's going on in DC, we believe it's playing into our hands. It's going to help us accelerate the technology and the platform sooner because if you want to lower your cost of drugs, you better make them cheaper. If you want to make more of them, you better make them cheaper. I want to stretch the dollars you don't have or less dollars to live on, you better make more for less. And that's the message, and I think that's the message we've been resonating. That's common sense, so I don't know what's going on in DC, but I think that.
You better find a more efficient way of doing.
And we've had discussions.
Phone yesterday at 1:30 with a senior person at the FDA. I have a call with on Friday.
There There's things going on. I don't know if they're going to turn in any money, but they're happening and I think everybody's realizing cost of goods matters because without that we have an unsustainable model in America, little across the globe.
So this may actually be working out ditic favor. And also the whole twist about MRNA vaccines. I'm not saying whether they're safe or not. I'm not going to get into that debate, but this hesitancy that's been created for the MRNA vaccines. So if we take a step back, which is what I think that that RFK and Trump are doing on MRNA, it may open up the door for the spotlight to be focused on a more durable, faster, lower cost.
Girls.
Thanks, I think, yeah.
I think it's, we've got a really good outlook here. So keep up the good work.

Operator

Okay, we'll look with that doesn't look like there are any more questions. I'd like to pass the call back to Mark Emelfar for closing remarks.

Mark Emalfarb

Well, I almost feel like we're already done, but I'll close it anyway. Okay.
Looking ahead to 2025 and beyond, our strategic priorities are clear and focused. We're launching our first commercial products. We're expanding strategic partnerships and alternative proteins and industrial biomaterials. We're broadening the adoption of our microbial platforms across numerous markets.
We're preparing to launch our first commercial product and combinant albumin, non-animal dairy, DNAse one, cellulosic enzymes, making a major milestone in dyetics evolution from biomanufacturing platform development to revenue generation. At the same time, we plan to expand strategic partnerships across key sectors including the alternative protein section, segment, diagnostics, research tools, leveraging the growing interest in sustainable, animal-free, and high performance protein solutions.
We will also continue to leverage our proprietary C1 and D of platforms to meet the rising global demand for affordable and efficient biomanufacturing technologies across all the markets with a strong IP portfolio and an expanding product pipeline and increasing global recognition, Diadtic is well positioned to be a disrupter in the biomanufacturing space and a revenue generating engine delivering tangible near term value for shareholders.
Our C1 adapt of its platforms are engineered to maximize efficiency, ensuring that funding goes further to meet the needs for more efficient, high yield protein production in today's rapidly evolving landscape.
We're excited about the opportunities that lie ahead and remain committed to driving innovation, accessibility, and growth across all areas of our business.
Thank you for joining today's call and a special thank you to our investors, partners, employees, and board members who have made 2024 a standout year. We look forward to delivering continued growth and innovation in 2025 and beyond.

Operator

Thank you and with that this conference has now concluded.
Thank you for attending today's presentation. You may now disconnect your lines.