Santhera Launches Senior Convertible Bond Issue

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Liestal, Switzerland, February 10, 2017 - Santhera Pharmaceuticals (SIX: SANN) announces the launch of an offering of CHF 50 million senior unsecured convertible bonds (the "Convertible Bonds") due 2022 with the possibility of an increase by a maximum of CHF 10 million to CHF 60 million.

Santhera intends to use the net proceeds from this placement primarily to fund the commercialization of Raxone® in the currently approved indication, to prepare the market entry and commercial launch in subsequent indications, for investment into further clinical trials with Raxone and for other corporate purposes.

The Convertible Bonds have a 5-year maturity, are expected to carry a coupon of between 4.5% and 5.0% per annum, payable semi-annually in equal instalments in arrear, and have a Conversion Price set at a premium of 20% to 25% over the volume weighted average price (VWAP) of the shares today between launch and pricing (the "Reference Share Price"). The Conversion Price will be reset after the first year if the VWAP of the shares during a specified period of time will be below the Reference Share Price. The new Conversion Price must not be lower than 75% of the Conversion Price at issuance. In addition, Santhera may call the Convertible Bonds at any time on or after the second anniversary of the issue date at par, plus accrued interest, if any, if the VWAP of the shares is at least 160% of the Conversion Price.

The number of shares to be delivered upon conversion shall be sourced from conditional capital and, if needed, authorized capital. Subject to the approval by the Annual Shareholders` Meeting on April 4, 2017, the Board of Directors plans to increase conditional capital by an amount that is sufficient to satisfy all conversion rights attached to the Convertible Bonds by delivery of shares solely out of the Company`s conditional capital. The preemptive rights of the shareholders to subscribe the Convertible Bonds have been excluded for this offering.

The final terms of the Convertible Bonds will be determined through an institutional bookbuilding process and are expected to be announced later today after the conclusion of the process.

Application will be made for the Convertible Bonds to be admitted for listing and trading on the SIX Swiss Exchange, with provisional trading expected to start on or around February 16, 2017. Payment and settlement of the Convertible Bonds is expected to be on or around February 17, 2017.