In This Article:
Study Published in a special issue of International Journal of Molecular Sciences Confirms Test's Ability to Distinguish Early Lung Cancer from Other Non-Cancerous Lung Diseases
Vancouver, British Columbia--(Newsfile Corp. - May 12, 2025) - BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTCQB: BMKDF) ("BioMark"), a leading developer of liquid biopsy tests for early cancer detection, today announced the publication of a pivotal study as part of the special issue Molecular Pathogenesis and Diagnostics of Lung Diseases of the International Journal of Molecular Sciences. The research, titled "Clinical Validation of Plasma Metabolite Markers for Early Lung Cancer Detection", provides significant external validation for BioMark's metabolomics and machine learning powered technology, particularly highlighting its high specificity and accuracy in detecting early-stage non-small cell lung cancer (NSCLC) and differentiating it from other non-cancerous lung conditions.
The study utilized a large, clinically diverse patient cohort, analyzing 680 archived plasma samples in a discovery cohort and an independent set of 216 plasma samples for validation. A key strength of the research was the composition of the control group, which included not only healthy individuals but also patients with various non-cancerous lung diseases. This design allowed for a rigorous assessment of the test's ability to accurately identify lung cancer, minimizing the potential for false positives due to other lung conditions.
Dr. Jean-François Haince, Chief Scientific Officer of BioMark, commented, "We are exceptionally pleased with these results, which builds upon our previous research using a much larger and more clinically complex patient cohort. The inclusion of patients with non-malignant lung conditions in our control group was crucial for truly testing the specificity of our metabolite panel. The models achieved Area Under the ROC Curve (AUROC) values of over 93% for distinguishing stage I-II NSCLC from the complex control group. The high AUROC values achieved, especially for the earliest stages of lung cancer, confirm the robustness of our metabolomic and machine learning approach. This validation is a significant step forward in advancing our liquid biopsy technology towards broader clinical adoption to aid in early cancer diagnosis and management."
"This publication in a respected peer-reviewed journal is a tremendous milestone for BioMark and a powerful external validation of our team's dedicated work," said Rashid Ahmed Bux, President and CEO of BioMark Diagnostics. "The study's demonstration of high accuracy, particularly its ability to differentiate early-stage cancer from other lung diseases, is critical. It gives us, and the clinical community, greater confidence in our test's potential to become an essential tool in the fight against lung cancer, where early detection is paramount for improving patient survival rates."