Nexalin Technology Secures USPTO Patent for Deep Intracranial Frequency Stimulation (DIFS™) Technology in Treating Substance Use Disorders

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Nexalin Technology, Inc.
Nexalin Technology, Inc.

Patent Approval Reinforces Nexalin’s Leadership in Non-Invasive Brain Stimulation for Addiction Treatment

HOUSTON, TX, April 14, 2025 (GLOBE NEWSWIRE) -- Nexalin Technology, Inc. (Nasdaq: NXL; NXLIW) (the “Company” or “Nexalin”) the leader in Deep Intracranial Frequency Stimulation (DIFS™) of the brain, is pleased to announce that the United States Patent and Trademark Office (USPTO) has officially granted its patent titled "Alternating Current Dynamic Frequency Stimulation Method for Opioid Use Disorder (OUD) and Substance Use Disorder (SUD)."

This milestone further strengthens Nexalin’s intellectual property portfolio and affirms the potential of its proprietary Deep Intracranial Frequency Stimulation (DIFS™) technology, a non-invasive and drug-free solution designed to aid individuals struggling with substance use disorders (SUDs), including opioid use disorder (OUD), alcohol use disorder (AUD), and stimulant addiction such as cocaine and methamphetamine dependence. By applying non-invasive deep-brain stimulation at dynamic frequencies, DIFS™ technology may help regulate neural pathways linked to addiction and withdrawal symptoms, offering an alternative treatment pathway for individuals seeking recovery.

Mark White, CEO of Nexalin Technology, remarked, “Securing this patent grant from the USPTO is a significant achievement for Nexalin as we continue to push the boundaries of non-invasive brain stimulation. Substance use disorders remain one of the greatest public health challenges worldwide, and our DIFS™ technology has the potential to introduce a transformative approach to treatment. With this official patent in place, we are further cementing our role as pioneers in the field of addiction and mental health therapy with a safe and effective brain-based treatment. Chronic relapse among individuals with substance use disorders is often driven by underlying anxiety, depression, and persistent cravings. Our DIFS™ technology is designed to address these core symptoms through targeted neuromodulation. By potentially alleviating anxiety and depression, DIFS™ may also reduce the cravings that lead to relapse—offering a promising pathway to improved treatment outcomes and long-term recovery.”

Millions of individuals worldwide are affected by substance use disorders, including opioid dependency, alcoholism, and stimulant abuse. While traditional treatment methods such as medication-assisted therapy (MAT) and behavioral interventions exist, they come with accessibility issues, pharmaceutical dependency, and potential side effects. Nexalin’s DIFS™ technology represents a forward-thinking alternative, aiming to ease withdrawal symptoms and support long-term recovery without the risks associated with conventional therapies.