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• Nykode’s APC targeted vaccine technology can be delivered as mRNA and generate strong T cell responses

• Nykode’s APC targeted vaccine technology consistently results in faster, broader and stronger immune response compared to non-targeted vaccines, whether delivered as DNA or mRNA

OSLO, Norway, Oct. 09, 2023 (GLOBE NEWSWIRE) -- Nykode Therapeutics ASA (OSE: NYKD), a clinical-stage biopharmaceutical company dedicated to the discovery and development of novel immunotherapies, today announced it is presenting at the annual mRNA Cancer Vaccines Summit in Boston, Massachusetts on October 12th.

Mikkel W. Pedersen, Chief Scientific Officer at Nykode will present preclinical data highlighting the differentiating factors of Nykode’s proprietary vaccine technology. When delivered either via DNA or mRNA, Nykode’s Antigen presenting cells (APC)-targeted cancer vaccines lead to a faster and broader T cell response compared to standard mRNA vaccines with identical antigens in a head-to-head comparison. There is almost a doubling of the number of antigens that are immunogenic when targeted to APCs, and the responses are primarily driven by CD8 T cells.

“These data demonstrate the strength of Nykode’s APC targeted technology to drive relevant T cell responses for cancer immunotherapy whether we use the DNA or mRNA format. Simultaneous induction of CD8 T cell responses to multiple different cancer-specific antigens holds the key to successful anti-cancer immune interventions. It is exciting to see that our unique mechanism of action targeting tumor antigens to APC leads to this unique and differentiated response,” says Mikkel W. Pedersen.

“We are very excited with these data showing that whether delivered as DNA or mRNA, Nykode’s technology results in superior immune responses. We now see the potential of Nykode’s vaccine technology to also improve the current mRNA cancer vaccines” says Michael Engsig, CEO of Nykode. “Combined with the long and durable responses observed to date in our clinical trials applying Nykode’s vaccines as DNA, we are very optimistic about the future broad application of the Vaccibody platform in the development of cancer vaccines.”

Details for the Nykode Therapeutics’ presentation are as follows:

Title: Opportunities to improve mRNA Cancer Vaccines
Time & Date: 10.00am ET, October 12, 2023

About Nykode Therapeutics
Nykode Therapeutics is a clinical-stage biopharmaceutical company dedicated to the discovery and development of novel immunotherapies with a focus on treatment of cancer and autoimmune diseases. Nykode’s modular vaccine technology specifically targets antigens to APC, which have been shown to induce broad, strong and long-lasting antigen specific immune responses which correlates with clinical responses in cancer.